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Gout and NLRP3 Inflammasome Biology — Arthritis & Rheumatology

Revision cc79a40f-66ef-45ed-b3af-26760ad1dd48 · 9/26/2026, 8:21:32 PM UTC

Key: poulsen-dalbeth-2025-gout-nlrp3
Authors: Poulsen, Raewyn; Dalbeth, Nicola
Issued: 2025-6-25
Type: article-journal
Container: Arthritis & Rheumatology
Volume: 77
Pages: 1317-1326
DOI: 10.1002/art.43215
URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC12479186/

Raw CSL JSON

{
  "DOI": "10.1002/art.43215",
  "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12479186/",
  "page": "1317-1326",
  "type": "article-journal",
  "PMCID": "PMC12479186",
  "title": "Gout and NLRP3 Inflammasome Biology",
  "author": [
    {
      "given": "Raewyn",
      "family": "Poulsen"
    },
    {
      "given": "Nicola",
      "family": "Dalbeth"
    }
  ],
  "issued": {
    "date-parts": [
      [
        2025,
        6,
        25
      ]
    ]
  },
  "volume": "77",
  "container-title": "Arthritis & Rheumatology"
}

Claims

nlrp3-initiation

A gout flare proceeds through initiation, leucocyte mobilization and self-resolution; activation of the NLRP3 inflammasome and release of mature interleukin-1β from monocytes and macrophages is central to initiating it.

"Like all acute inflammatory responses, there are three broad stages of gout flare: initiation, leucocyte mobilization, and self-resolution. ... Activation of the NLRP3 inflammasome and release of mature interleukin-1β (IL-1β) from monocytes and macrophages is central to initiation of gout flare."

Locator: section: Immune mechanisms of gout flare · Quote language: en

Available in

en - English