CITATION — REFERENCE ENTRY
Global, regional, and national burden of gout, 1990–2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021 — The Lancet Rheumatology
- Key
- gbd-2024-gout-burden
- Authors
- GBD 2021 Gout Collaborators
- Issued
- 2024-7-9
- Type
- article-journal
- Container
- The Lancet Rheumatology
- Volume
- 6
- Issue
- 8
- Pages
- e507-e517
Raw CSL JSON
{
"DOI": "10.1016/S2665-9913(24)00117-6",
"URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11263476/",
"PMID": "38996590",
"page": "e507-e517",
"type": "article-journal",
"PMCID": "PMC11263476",
"issue": "8",
"title": "Global, regional, and national burden of gout, 1990–2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021",
"author": [
{
"literal": "GBD 2021 Gout Collaborators"
}
],
"issued": {
"date-parts": [
[
2024,
7,
9
]
]
},
"volume": "6",
"container-title": "The Lancet Rheumatology"
}
Claims
-
Risk factors for gout include obesity, metabolic syndrome and chronic kidney disease, and gout is associated with cardiovascular, metabolic and renal comorbidities.
"Many factors that contribute to hyperuricaemia are also risk factors for incident gout, including obesity, metabolic syndrome, and chronic kidney disease, factors commonly seen in younger people with gout. Gout has been associated with cardiovascular, metabolic, and renal comorbidities."
-
The highest age-standardised gout prevalence in 2020 was in high-income North America (1,719.8 per 100,000) and Australasia (1,424.4 per 100,000).
"high-income North America (1719·8 ... per 100 000), Australasia (1424·4 ... per 100 000)"
-
Māori and Pacific peoples in New Zealand have disproportionately severe gout compared with New Zealand Europeans, developing severe disease younger, with more frequent flares, more hospital admissions, and more tophaceous disease.
"Maori and Pacific Islanders in New Zealand have severe gout disproportionately compared with New Zealand Europeans, developing severe disease at a younger age, with more frequent flares, higher rates of hospital admission for gout, and more tophaceous disease"
-
An estimated 55.8 million people worldwide had gout in 2020, an age-standardised prevalence of 659.3 per 100,000, up 22.5% since 1990.
"55·8 million (95% uncertainty interval 44·4–69·8) people globally had gout, with an age-standardised prevalence of 659·3 (525·4–822·3) per 100 000, an increase of 22·5% (20·9–24·2) since 1990"
-
Prevalent cases of gout are projected to reach 95.8 million worldwide by 2050, a 72.6% increase from 2020.
"95·8 million (81·1–116) prevalent cases of gout globally ... an increase of 72·6% (54·9–100·3) from 2020 to 2050"
-
High body-mass index accounted for 34.3% of years lived with disability due to gout in 2020, and kidney dysfunction for 11.8%.
"High BMI accounted for 34·3% (27·7–40·6) of YLDs ... kidney dysfunction accounted for 11·8% (9·3–14·2)"
-
In 2020 gout prevalence was 3.26 times higher in males than in females and increased with age.
"The prevalence of gout in 2020 was 3·26 (3·11–3·39) times higher in males than in females and increased with age."
-
Only a third to half of people with gout receive urate-lowering therapy, and fewer than half of those adhere to it.
"only a third to half of patients with gout receiving urate-lowering therapy, and fewer than half ... adhering to ... treatment"
-
In a gout registry, women more often had kidney disease and used thiazide or other diuretics, while men more often reported eating foods associated with gout.
"Women more often have renal disease and concomitant use of thiazides or other diuretics. Men are more likely to report intake of foods associated with both the development of gout and gout flares"
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