CITATION — REFERENCE ENTRY
no-uricase · ahn-so-2024-pathogenesis-of-gout
- Citation
- ahn-so-2024-pathogenesis-of-gout
- Claim ID
- no-uricase
- Assertion
- Most mammals convert uric acid to soluble allantoin with the enzyme uricase, but humans and other apes lack uricase, so uric acid is the end product of purine metabolism.
- Quote
Uric acid can be metabolized into allantoin by uricase in most mammals, and allantoin is highly water-soluble and readily excreted. However, humans and certain other primates, including chimpanzees, gorillas, orangutans and gibbons, lack uricase, so uric acid is the end product of purine metabolism
- Quote language
- en
- Locator
- section: Hyperuricemia
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