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Copaifera langsdorffii oleoresin and its isolated compounds: antibacterial effect and antiproliferative activity in cancer cell lines — BMC Complementary and Alternative Medicine

Revision 1003010e-64e5-4590-a13c-31c2cabe88fb · 4/29/2026, 1:06:07 PM UTC
Key
abrao2015antibacterial
Authors
Abrão, Fariza; de Araújo Costa, Luciana Delfino; Alves, Jacqueline Morais; Senedese, Juliana Marques; de Castro, Pâmela Tinti; Ambrósio, Sérgio Ricardo; Veneziani, Rodrigo Cássio Sola; Bastos, Jairo Kenupp; Tavares, Denise Crispim; Martins, Carlos Henrique G.
Issued
2015-12-21
Type
article-journal
Container
BMC Complementary and Alternative Medicine
Volume
15
Pages
443
Raw CSL JSON
{
  "DOI": "10.1186/s12906-015-0961-4",
  "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4687089/",
  "PMID": "26691920",
  "page": "443",
  "type": "article-journal",
  "PMCID": "PMC4687089",
  "title": "Copaifera langsdorffii oleoresin and its isolated compounds: antibacterial effect and antiproliferative activity in cancer cell lines",
  "author": [
    {
      "given": "Fariza",
      "family": "Abrão"
    },
    {
      "given": "Luciana Delfino",
      "family": "de Araújo Costa"
    },
    {
      "given": "Jacqueline Morais",
      "family": "Alves"
    },
    {
      "given": "Juliana Marques",
      "family": "Senedese"
    },
    {
      "given": "Pâmela Tinti",
      "family": "de Castro"
    },
    {
      "given": "Sérgio Ricardo",
      "family": "Ambrósio"
    },
    {
      "given": "Rodrigo Cássio Sola",
      "family": "Veneziani"
    },
    {
      "given": "Jairo Kenupp",
      "family": "Bastos"
    },
    {
      "given": "Denise Crispim",
      "family": "Tavares"
    },
    {
      "given": "Carlos Henrique G.",
      "family": "Martins"
    }
  ],
  "issued": {
    "date-parts": [
      [
        2015,
        12,
        21
      ]
    ]
  },
  "volume": "15",
  "container-title": "BMC Complementary and Alternative Medicine"
}

Claims

  1. The diterpene (-)-copalic acid, isolated from C. langsdorffii oleoresin, showed the strongest antibacterial activity among the compounds tested, with promising minimum inhibitory concentration (MIC) values against multiresistant Gram-positive bacteria. It also showed antiproliferative activity against cancer cell lines, with the lowest IC50 found for a human glioblastoma cell line.
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